ISSN: 1300-0330
Dil: Türkçe, İngilizce
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A Case Of Pyoderma Gangrenosum Associated With Myelofibrosis
Müzeyyen GÖNÜL, MD,a Seray KÜLCÜ ÇAKMAK, MD,a Ülker GÜL, MD,a Arzu KILIÇ, MD,a Murat DEMİRİZ, MD,b Özlem DEMİREL, MDa
a2nd Dermatology Clinics, Ankara Numune Training and Research Hospital bDepartment of Pathology, GATA, ANKARA
Pyoderma gangrenosum (PG) is a rare, destructive and inflammatory skin disease. Associated systemic disorders are observed in half of the cases. Association with myeloproliferative disorders have been reported frequently among the hematologic disorders but association with myelofibrosis has been reported very rarely. A 35-year-old man with myelofibrosis since 11 years was consulted to our clinic because of the lesions localized on the injection area on his left arm. On dermatological examination a 2x3 cm sized bullous lesion on a sharp bordered erythematous plaque was observed. The lesion spread peripherally and changed to 15x20 cm sized, sharp bordered, ulcerated lesion with a purple halo in 10 days. Hystopathological examination of the lesion was consistent with PG. We report our case as PG associated with myelofibrosis is very rare and the development of the lesion after the injection points out to the pathergy phenomenon in the PG.Keywords: Pyoderma gangrenosum, myelofibrosisTurkiye Klinikleri J Dermatol 2008, 18:33-36
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