ISSN: 1300-0330
Dil: Türkçe, İngilizce
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The Lines Of Blaschko
Dr. Muhterem POLAT,a Dr. Pınar ÖZTAŞ,a Dr. Emine TAMER,a Dr. Nuran ALLIa
a1. Dermatoloji Kliniği, Ankara Numune Eğitim ve Araştırma Hastanesi, ANKARA
The lines of Blaschko represent a nonrandom developmental pattern of the skin fundamentally differing from the system of dermatomes. Many skin lesions display an arrangement following these lines. A causal relationship between lyonization and the lines of Blaschko seems quite obvious. Although it should be borne in mind that other genetic mechanisms such as somatic mutations or chimerism may give rise to the same linear pattern, the datable embryologic event of X-inactivation seems most suitable to explain the origin and the nature of the lines of Blaschko. A new concept is functional automosomal mosaicism transmittible through the action of transpozons, and may explain the Blaschko lines in human skin. It is now clear that these lines are inde-pendent from the metameric structure of the human body. Obviously, they represent a marker of the normal development of human skin.Keywords: Blashko’s lines, hyperpigmentationTurkiye Klinikleri J Dermatol 2007, 18:17-21
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