ISSN: 1300-0330
Dil: Türkçe, İngilizce
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Lipoatrophy (lipodystrophy)
Dr. Emel ERKEKa
aDermatoloji AD, Kırıkkale Üniversitesi Tıp Fakültesi, KIRIKKALE
Subcutaneous tissue is composed of fat lobules, connective tissue, blood vessels, nerves and lymphatics. It is bound tightly to the dermis and loosely to the underlying superficial fascia and facilitates sliding of the skin over the fascia. Adipose tissue determines body contours, acts as a heat insulator, shock-absorbent and nutritional depot. It is currently classified as an endocrine organ, since it is endowed with the capacity to produce several adipokines. Apart from the glucose and lipid metabolism, this peculiar organ has the ability to influence immune, reproductive and hemopoietic functions. Although dermatologists are involved in the diagnosis and treatment of adipose tissue disorders, the dermatology literature is devoid of studies and reviews regarding the subcutaneous tissue. Lipoatrophy (lipodystrophy) denotes a group of rarely encountered disorders characterized by the loss of subcutaneous tissue. Such disorders have shed light on the fundamental functions of the subcutaneous tissue in metabolic and endocrine grounds. Prior to the last decade, there were only a few hundred published articles on lipoatrophy. The number of publications has accelerated since the HIV epidemic. The follow-up and treatment of patients with lipoatrophy requires a multidisciplinary approach with involvement of physicians from Dermatology, Endocrinology, Cardiology, Internal Medicine and Infectious Diseases departments. Currently, disorders with lipoatrophy are encountered more frequently and several ongoing studies aim at assessing their optimum therapy. The present article aims at providing updated information on the classification, clinicopathological features and management of disorders presenting with the loss of subcutaneous tissue, namely lipoatrophy (lipodistrophy).Keywords: Diabetes mellitus, lipoatrophic; HIV-associated lipodystrophy syndromeTurkiye Klinikleri J Dermatol 2007, 17:252-264
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